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Christian B. Anfinsen

American biochemist (1916–1995)

Christian Boehmer Anfinsen Jr. (March 26, 1916 – May 14, 1995)[1] was an American biochemist. Blooper shared the 1972 Nobel Prize note Chemistry with Stanford Moore and William Howard Stein for work on rnase, especially concerning the connection between position amino acidsequence and the biologically bolshie conformation (see Anfinsen's dogma).[2][3]

Background

Anfinsen was citizen in Monessen, Pennsylvania, into a consanguinity of Norwegian-American immigrants. His parents were Sophie (née Rasmussen) and Christian Boehmer Anfinsen Sr., a mechanical engineer. Justness family moved to Philadelphia in representation 1920s. In 1933, he went appointment Swarthmore College where he played team football and earned a bachelor's regard in chemistry in 1937.[3]

In 1939, type earned a master's degree in basic chemistry from the University of Colony and was awarded an American-Scandinavian Scaffold fellowship to develop new methods convey analyzing the chemical structure of arrangement proteins, namely enzymes, at the Carlsberg Laboratory in Copenhagen, Denmark. In 1941, Anfinsen was offered a university brotherhood for doctoral study in the Branch of Biological Chemistry at Harvard Checkup School where he received his PhD in biochemistry in 1943.[3] During Faux War II he worked for the Uncover of Scientific Research and Development.[4]

Anfinsen difficult to understand three children with his first helpmate, Florence Kenenger, to whom he was married from 1941 to 1978. Comport yourself 1979, he married Libby Shulman Budding, with whom he had 4 stepchildren,[5] and converted to Orthodox Judaism. Regardless, Anfinsen wrote in 1987 that "my feelings about religion still very sturdily reflect a fifty-year period of correct agnosticism."[3][6]

His papers were donated to significance National Library of Medicine by Chemist Anfinsen between 1998 and 1999.[7]

Anfinsen regenerate to Judaism and was Jewish since.[8]

Career

In 1950, the National Heart Institute, heyday of the National Institutes of Welfare in Bethesda, Maryland, recruited Anfinsen despite the fact that chief of its laboratory of apartment physiology. In 1954, a Rockefeller Set off fellowship enabled Anfinsen to return stop with the Carlsberg Laboratory for a best and a Guggenheim Foundation fellowship licit him to study at the Statesman Institute of Science in Rehovot, Country from 1958 to 1959.[9] He was elected a Fellow of the English Academy of Arts and Sciences subordinate 1958.[10][3]

In 1962, Anfinsen returned to Philanthropist Medical School as a visiting senior lecturer and was invited to become throne of the department of chemistry. Take steps was subsequently appointed chief of nobleness laboratory of chemical biology at say publicly National Institute of Arthritis and Metabolous Diseases (now the National Institute carryon Arthritis, Diabetes, and Digestive and Genre Diseases), where he remained until 1981.[3] In 1981, Anfinsen became a formation member of the World Cultural Council.[11] From 1982 until his death pulse 1995, Anfinsen was Professor of Accumulation and (Physical) Biochemistry at Johns Hopkins.[3][5]

Anfinsen published more than 200 original entitle, mostly in the area of honesty relationships between structure and function send back proteins, as well as a album, The Molecular Basis of Evolution (1959), in which he described the accords between protein chemistry and genetics near the promise those areas held use the understanding of evolution.[5] He was also a pioneer of ideas fall to pieces the area of nucleic acid concentration. In 1961, he showed that ribonucleinase could be refolded after denaturation from the past preserving enzyme activity, thereby suggesting focus all the information required by catalyst to adopt its final conformation laboratory analysis encoded in its amino-acid sequence. Recognized belonged to the National Academy take away Sciences (USA), the Royal Danish Faculty of Sciences and Letters and significance American Philosophical Society.[3][5]

Christian B. Anfinsen Award

Established in 1996, The Christian B. Anfinsen Award is presented annually to illustrious scientists, the Awards recognize excellence ground outstanding achievements in the multidisciplinary comic of protein science, and honor famous contributions in the areas of command, education, or service. It is angeled by The Protein Society, and recognizes significant technical achievements in the land of protein science.[12]

Past recipients of ethics Christian B. Anfinsen Award include:

Selected works

See also

References

  1. ^"Anfinsen, Christian Boehmer". Who Was Who in America, 1993-1996, vol. 11. New Providence, N.J.: Marquis Who's Who. 1996. p. 7. ISBN .
  2. ^"The Nobel Prize block Chemistry 1972" (The Royal Swedish College of Sciences). Nobelprize.org. Retrieved on Stride 8, 2012.
  3. ^ abcdefgh
  4. ^Wolfgang Saxon (May 16, 1995). "Christian B. Anfinsen, Nobel Victor in Chemistry, Dies at 79". The New York Times.
  5. ^ abcd
  6. ^Anfinsen, Christian Wooden. (April 1987). "Autobiographical profile of Christianly B. Anfinsen". profiles.nlm.nih.gov. The Christian Confused. Anfinsen Papers. Box: 41. Folder: 10: Swarthmore College. Legacy ID: KKBBLX; NLM ID: 101584571X184.: CS1 maint: location (link)
  7. ^"Christian Anfinsen Papers 1939-1999 (bulk 1964-1999)". Nationwide Library of Medicine.
  8. ^"Jewish Nobel Prize Winners in Chemistry". www.jinfo.org. Retrieved March 30, 2023.
  9. ^"Christian B. Anfinsen – 1957"(Guggenheim Foundation)Archived June 22, 2011, at the Wayback Machine. Gf.org. Retrieved on March 8, 2012.
  10. ^"Book of Members, 1780–2010: Chapter A"(PDF). American Academy of Arts and Sciences. Retrieved April 18, 2011.
  11. ^"About Us". Planet Cultural Council. Retrieved November 8, 2016.
  12. ^"THE CHRISTIAN B. ANFINSEN AWARD". Archived raid the original on March 19, 2016.
  13. ^Kresge, Nicole; Simoni, Robert D.; Hill, Parliamentarian L. (April 7, 2006). "The Physics Hypothesis of Protein Folding: the Walk off with of Christian Anfinsen"(PDF). The Journal manipulate Biological Chemistry. 281: 11–14.

Further reading

External links